OBJECTIVES

• Explain the strain variation in Mycobacterium tuberculosis - Apply genetics aspects used to mycobacterial differentiation
• Identify geographic distribution and the impact of mycobacterial types locally and globally

• Basics of mycobacterial genome
• The main groups of Mycobacteria
  • Mycobacterium tuberculosis Complex
  • M. tuberculosis families
• What is phylogenetic?
• Genomic plasticity in mycobacteria
  • large sequence polymorphism (LSP)
  • interspersed repetitive units
  • tandem repeats (TR)
  • PE and PPE Proteins
• Muller's ratchet
• Ecotype model
• DNA fingerprints
• Genetic markers for Mycobacteria differentiation
• Geographic distribution of M. tuberculosis (local VS global molecular epidemiology)
• Bacterial genetic variation and considerations to approach vaccines and treatment schemas

REFERENCES

lenski2017.pdf

9. Genomics of the Mycobacterium tuberculosis complex.pdf

17. Molecular Evolution of Mycobacteria (1).pdf

Metagenomics as a Tool for Enzyme Discovery.pdf

The nature and evoltuion of genomic Diversity in the Mycobacterium tuberculosis complex.pdf